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Balasubramanian, Arul
- Comparative Efficacy of Typical and Atypical Anti Psychotics in the Treatment of Acute Mania
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Authors
Arul Balasubramanian
1,
Kothai Ramalingam
1,
Rahul Radhakrishanan
1,
Rini John
1,
Y. Nadeem Arafath
1
Affiliations
1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636008, Tamil Nadu, IN
1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636008, Tamil Nadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2804-2808Abstract
Objective: The study assessed the efficacy of typical and atypical antipsychotics as combination therapy with mood stabilizers in the treatment of acute mania in a tertiary care hospital in Salem District of Tamil Nadu. Method: A retrospective observational study was carried out among 52 acute mania patients who received combination therapy with either atypical antipsychotics or typical antipsychotics with mood stabilizers. The primary efficacy measures were severity and improvement score with Clinical Global Impression scale (CGI) and Extrapyramidal side effects (EPS). Results: The study was conducted in 52 acute mania patients, in which 31 patients treated with atypical antipsychotics + mood stabilizers and 21 patients treated with typical antipsychotics + mood stabilizers. On analyzing the patients with the CGI-S scale, patients treated with atypical antipsychotics and mood stabilizers showed a significant reduction in the severity. Further, when analyzing with CGI-I Scale and EPS, it showed significant improvement in the clinical condition and less EPS in the patients treated with atypical antipsychotics with mood stabilizers. Conclusion: Atypical antipsychotics can be considered as the first choice for combination therapy with a mood stabilizer for the treatment of acute mania compared to typical antipsychotics due to their better efficacy, less extrapyramidal side-effects and shortens the duration of hospital stay.Keywords
Mania, Antipsychotics, Mood Stabilizers, Extrapyramidal Side Effects.
References
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- Effect of Gymnema sylvestre Extract on the Regulation of AMPK-GLUT4 Mediated Signaling Pathway on Insulin Resistance in a PCOS Rat Model
Abstract Views :188 |
PDF Views:74
Authors
Affiliations
1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem - 636308, Tamil Nadu, IN
1 Department of Pharmacology, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem - 636308, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 429-439Abstract
This study was intended to assess the effect of Gymnema sylvestre leaf extract on the AMPK-GLUT4 mediated signalling pathway on insulin resistance in polycystic ovarian syndrome-induced rats. For the induction of PCOS in rats, 1 mg/kg of letrozole was given orally for 21 days, after that metformin (300 mg/kg), Gymnema sylvestre leaf extract (200 mg/kg, and 400 mg/kg p. o.) were administered for further 28 days. Letrozole-induced PCOS rats illustrated significant estrus irregularity, and sex hormonal abnormality, and developed insulin resistance as indicated by increased fasting glucose levels, an increased rate of glucose clearance, and also decreases in GLUT4 and AMPK mRNA expression in ovarian cells. Ovarian histology in PCOS rats also showed many follicular cysts, atretic follicles, and the absence of the corpus luteum. These changes were significantly reversed by the treatment of G. sylvestre in a dose-dependent manner. It might be mediated through its insulin resistance modulating property by the activation of AMPK & GLUT4 expression on ovarian endometrial cells.Keywords
Gymnema sylvestre, Insulin Resistance, Letrozole, Metformin, Polycystic Ovary SyndromeFull Text
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